GUILLAIN BARRE SYNDROME (GBS)-POOR PROGNOSIS

SUMMARY

PATIENT FACTORS
1. Older age (> 50 years)

DISEASE FACTORS
2. Subgroup of GBS with primary axonal degeneration
3. Rapid onset
4. Progression to quadriplegia
5. Respiratory dependence
6. Severe disease at presentation
7. Campylobacter jejuni infection

8. Patients showing no improvement at 3 weeks of plateau of disease

TREATMENT FACTORS
9. Requirement for respiratory support
10. Abnormal peripheral nerve function
11. No plasmapheresis is performed

Reference(s)

Hallum A. Neuromuscular diseases. In: Neurological Rehabilitation. Umphred DA, ed. 4^th edn. St Louis: Mosby, 2001;363–415.

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].