Difference between revisions of "INTERCELLULAR CONNECTION-GAP JUNCTION"

Latest revision as of 02:30, 21 March 2023

SUMMARY

1. 3nm tunnels formed by connexons which line up with each other in adjacent cells. Each connexon is made up of 6 protein subunits called connexins.

2. Particular connexin subunits that make up connexons determine their permiability and selectivity.

3. Allows ions, sugars, amino acids, and anything < MW 1000, denies access to larger or negatively charged molecules.

4. Facilitates cell-cell communication.

5. Allow cardiac or smooth muscle to contract simultaneously.

6. Charcot-Marie-Tooth disease: X-linked, peripheral neuropathy assoc. with defective connexin gene.

Reference(s)

Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education

@@ Line 10: / Line 10: @@
 <br/>5. Allow cardiac or smooth muscle to contract simultaneously.
 <br/>
-<br/>6. Charcot-Marie-Tooth disease: X-linked, peripheral neuropathy a/w defective connexin gene.
+<br/>6. Charcot-Marie-Tooth disease: X-linked, peripheral neuropathy assoc. with defective connexin gene.
 ==Reference(s)==
-Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
+Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education
-<br/>Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
-<br/>West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.
 [[Category:Intercellular Connection]]
 [[Category:Physiology]]