Difference between revisions of "HYPERPARATHYROIDISM-PTH"

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===== [[Summary Article|'''SUMMARY''']] =====
===== [[Summary Article|'''SUMMARY''']] =====
FUNCTION
FUNCTION
<br/>1. Stimulates osteoclast activity ⟹ releases bone calcium stores.
<br/>1. Stimulates osteoclast activity ⟹ releases bone calcium stores.
<br/>2. Increases renal tubular calcium absorption + phosphate excretion.  
<br/>2. Increases renal tubular calcium absorption + phosphate excretion.  
<br/>3. Increases 1,25-dehydroxycholecalciferol (1,25-(OH)<sub>2</sub>D) production by increasing activity of kidney hydroxylase.  
<br/>3. Increases 1,25-dehydroxycholecalciferol (1,25-(OH)<sub>2</sub>D) production by increasing activity of kidney hydroxylase.  
<br/>
<br/>
<br/>CONTROLLED BY NEGATIVE FEEDBACK
<br/>CONTROLLED BY NEGATIVE FEEDBACK
<br/>4. High serum calcium ⟹ decreased parathyroid PTH production.  
<br/>4. High serum calcium ⟹ decreased parathyroid PTH production.  





Latest revision as of 02:29, 21 March 2023

SUMMARY

FUNCTION
1. Stimulates osteoclast activity ⟹ releases bone calcium stores.
2. Increases renal tubular calcium absorption + phosphate excretion.
3. Increases 1,25-dehydroxycholecalciferol (1,25-(OH)2D) production by increasing activity of kidney hydroxylase.

CONTROLLED BY NEGATIVE FEEDBACK
4. High serum calcium ⟹ decreased parathyroid PTH production.


Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].