View source for INTERCELLULAR CONNECTION-GAP JUNCTION

===== [[Summary Article|'''SUMMARY''']] =====
1. 3nm tunnels formed by connexons which line up with each other in adjacent cells. Each connexon is made up of 6 protein subunits called connexins. 
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<br/>2. Particular connexin subunits that make up connexons determine their permiability and selectivity. 
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<br/>3. Allows ions, sugars, amino acids, and anything &lt; MW 1000, denies access to larger or negatively charged molecules.
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<br/>4. Facilitates cell-cell communication. 
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<br/>5. Allow cardiac or smooth muscle to contract simultaneously.
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<br/>6. Charcot-Marie-Tooth disease: X-linked, peripheral neuropathy assoc. with defective connexin gene.


==Reference(s)==
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education 

[[Category:Intercellular Connection]]
[[Category:Physiology]]