View source for MND-POST POLIO SYNDROME (PPS) PATHOLOGY

===== [[Summary Article|'''SUMMARY''']] =====
1. Polio is transmitted orally, replicating in lymphoid tissue of the pharynx &amp; intestine and subsequently spreading haematologically to anterior horn cells.
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<br/>2. This results in destruction of the motor neurons, Wallerian degeneration and denervation of muscle fibres.
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<br/>3. 28-64% develop PPS.
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<br/>4. Death of remaining motor nerve cells due to ageing &amp; increasing metabolic demands leads to worsening weakness.
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<br/>5. Each cell is then responsible for activation more motor units than normal.
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<br/>6. More likely to have weakness and severe problems (breathing) with older onset (&gt; 35 yrs).


==Reference(s)==
Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. [https://amzn.to/3YHrI6K Get it on Amazon.]
<br/>Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. [https://amzn.to/3k7WSW0 Get it on Amazon.]
<br/>Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
<br/>Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].

[[Category:MND]]
[[Category:Neurology]]
[[Category:Medicine]]