View source for DIURETICS-THIAZIDE DIURETICS

===== [[Summary Article|'''SUMMARY''']] =====
1. Inhibits only 3 to 5% of sodium reabsorption.
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<br/>2. Inhibit the Na/CI co-transporter in the <b>early distal tubule.</b>
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<br/>3. Increase delivery of Na<sup>+</sup> to the <b>early distal tubule</b> and up-regulation of the counter-transport of the Na/K ATPase, leading to hypokalemia.
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<br/>4. Inhibit dilution of urine (main site in DCT): excess loss of electrolytes as compared to water excretion.
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<br/>5. Thiazides actually increase calcium reabsorption, which is in contrast with the action of loop diuretics - avoid in primary hyperparathyroidism or hypercalcemia of malignancy. 
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<br/>6. Thiazides can be useful in reducing urinary calcium in patients with kidney stones.


==Reference(s)==
Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
<br/>Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
<br/>Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].

[[Category:Diuretics]]
[[Category:Nephrology]]
[[Category:Medicine]]